Enter the Nanoman

Enter the ratrix.

U nderstanding the computations the brain performs to guide behavior largely relies on electrical recordings of action potentials generated by neurons in awake, behaving animals. Despite their widespread usage, the high density of neurons in cortex poses a significant limitation on the number of neighboring cells whose signals can be resolved even with state-of-the-art electrode-based methods. ...

Platelets Enter the Fray

A series of reports in 2007 established that single nucleotide polymorphisms (SNPs) in the 9p21.3 locus are associated with coronary heart disease (CHD), both in patients with acute myocardial infarction and chronic atherosclerosis.1–4 Subsequently, many additional studies used a candidate locus approach to replicate the 9p21.3-CHD association. Intriguingly, other phenotypes have also been foun...

Scientists Enter the Blogosphere

Blogs are one of the latest tools that scientists use to communicate their ideas to other scientists or to the general public. But who are the science bloggers and why do they blog?

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Proteasome degradation: enter the substrate.

Cells depend upon the regulated destruction of their various proteins to maintain homeostasis and change their metabolic state. A key component of this process is the proteasome - a large multisubunit protease whose catalytic sites are sequestered within a central chamber. Entry of substrates into proteasomes is regulated by activators and is generally thought to proceed sequentially, starting ...